Enhanced Shutoff of Phototransduction in Transgenic Mice
نویسندگان
چکیده
From the ‡Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, Massachusetts 02111, the ¶Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, the Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina 29425, and the **Department of Ophthalmology, Program in Genetics, Tufts Center for Vision Research, Tufts University School of Medicine, Boston, Massachusetts 02111
منابع مشابه
Signaling properties of a short-wave cone visual pigment and its role in phototransduction.
Although visual pigments play key structural and functional roles in photoreceptors, the relationship between the properties of mammalian cone pigments and those of mammalian cones is not well understood. We generated transgenic mice with rods expressing mouse short-wave cone opsin (S-opsin) to test whether cone pigment can substitute for the structural and functional roles of rhodopsin and to ...
متن کاملTransport of truncated rhodopsin and its effects on rod function and degeneration.
PURPOSE Most transgenic animal models of retinal degeneration caused by rhodopsin mutations express the rhodopsin transgene on a wild-type (WT) genetic background. Previous studies have demonstrated that one mechanism of retinal degeneration is rhodopsin overexpression. To study the effect of C-terminal truncation of rhodopsin without the confounding factors of overexpression, several lines of ...
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The shutoff mechanisms of the rod visual transduction cascade involve G-protein-coupled receptor (GPCR) kinase 1 (GRK1) phosphorylation of light-activated rhodopsin (R*) followed by rod arrestin binding. Deactivation of the cone phototransduction cascade in the mammalian retina is delineated poorly. In this study we sought to explore the potential mechanisms underlying the quenching of the phot...
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